The Scientific Validity of Curcumin

1. Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in 

Cardiovascular Diseases and Cancer Prevention.
Griffiths K, Aggarwal BB, Singh RB, Buttar HS, Wilson D, De Meester F.
Diseases. 2016 Aug 1;4(3). pii: E28. doi: 10.3390/diseases4030028. Review.

2. Calebin A, a novel component of turmeric, suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization.
Tyagi AK, Prasad S, Majeed M, Aggarwal BB.
Phytomedicine. 2017 Oct 15;34:171-181. doi: 10.1016/j.phymed.2017.08.021. 

Epub 2017 Aug 31.

3.Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.
Kunnumakkara AB, Bordoloi D, Harsha C, Banik K, Gupta SC, Aggarwal BB.
Clin Sci (Lond). 2017 Jul 5;131(15):1781-1799. doi: 10.1042/CS20160935. Print 2017 Aug 1. Review.
PMID: 28679846
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Select item 27638428
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.
Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB.
Br J Pharmacol. 2017 Jun;174(11):1325-1348. doi: 10.1111/bph.13621. Epub 2016 Oct 21. Review.
PMID: 27638428
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Select item 27025786
Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials.
Sahebkar A, Cicero AFG, Simental-Mendía LE, Aggarwal BB, Gupta SC.
Pharmacol Res. 2016 May;107:234-242. doi: 10.1016/j.phrs.2016.03.026. Epub 2016 Mar 26. Review.
PMID: 27025786
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Select item 26633709
Curcumin hormesis mediates a cross-talk between autophagy and cell death.
Rainey N, Motte L, Aggarwal BB, Petit PX.
Cell Death Dis. 2015 Dec 3;6:e2003. doi: 10.1038/cddis.2015.343. No abstract available.
PMID: 26633709 Free PMC Article
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Select item 26521943
Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin.
Tyagi AK, Prasad S, Yuan W, Li S, Aggarwal BB.
Invest New Drugs. 2015 Dec;33(6):1175-86. doi: 10.1007/s10637-015-0296-5. Epub 2015 Nov 2.
PMID: 26521943
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Select item 25547723
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Aggarwal BB, Deb L, Prasad S.
Molecules. 2014 Dec 24;20(1):185-205. doi: 10.3390/molecules20010185. Review.
PMID: 25547723 Free Article
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Select item 25157362
Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation.
Anthwal A, Thakur BK, Rawat MS, Rawat DS, Tyagi AK, Aggarwal BB.
Biomed Res Int. 2014;2014:524161. doi: 10.1155/2014/524161. Epub 2014 Jul 24.
PMID: 25157362 Free PMC Article
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Select item 24946050
Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.
Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB.
Arch Biochem Biophys. 2014 Oct 1;559:91-9. doi: 10.1016/ Epub 2014 Jun 16. Review.
PMID: 24946050
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Select item 24793420
Curcumin, a component of golden spice: from bedside to bench and back.
Prasad S, Gupta SC, Tyagi AK, Aggarwal BB.
Biotechnol Adv. 2014 Nov 1;32(6):1053-64. doi: 10.1016/j.biotechadv.2014.04.004. Epub 2014 Apr 30. Review.
PMID: 24793420
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Select item 24520218
Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice.
Prasad S, Tyagi AK, Aggarwal BB.
Cancer Res Treat. 2014 Jan;46(1):2-18. doi: 10.4143/crt.2014.46.1.2. Epub 2014 Jan 15. Review.
PMID: 24520218 Free PMC Article
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Select item 24283517
Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes.
Buhrmann C, Shayan P, Aggarwal BB, Shakibaei M.
Arthritis Res Ther. 2013;15(6):R202.
PMID: 24283517 Free PMC Article
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Select item 24280069
Curcumin glucuronides: assessing the proliferative activity against human cell lines.
Pal A, Sung B, Bhanu Prasad BA, Schuber PT Jr, Prasad S, Aggarwal BB, Bornmann WG.
Bioorg Med Chem. 2014 Jan 1;22(1):435-9. doi: 10.1016/j.bmc.2013.11.006. Epub 2013 Nov 12.
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Curcumin improves the therapeutic efficacy of Listeria(at)-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1.
Singh M, Ramos I, Asafu-Adjei D, Quispe-Tintaya W, Chandra D, Jahangir A, Zang X, Aggarwal BB, Gravekamp C.
Cancer Med. 2013 Aug;2(4):571-82. doi: 10.1002/cam4.94. Epub 2013 Jul 2.
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Select item 23847105
Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.
Aggarwal BB, Yuan W, Li S, Gupta SC.
Mol Nutr Food Res. 2013 Sep;57(9):1529-42. doi: 10.1002/mnfr.201200838. Epub 2013 Jul 12. Review.
PMID: 23847105
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Select item 23834173
Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment.
Hasima N, Aggarwal BB.
Curr Med Chem. 2014;21(14):1583-94. Review.
PMID: 23834173
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Select item 23425071
Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.
Aggarwal BB, Gupta SC, Sung B.
Br J Pharmacol. 2013 Aug;169(8):1672-92. doi: 10.1111/bph.12131. Review.
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Select item 23339055
Curcumin, a component of turmeric: from farm to pharmacy.
Gupta SC, Kismali G, Aggarwal BB.
Biofactors. 2013 Jan-Feb;39(1):2-13. doi: 10.1002/biof.1079. Epub 2013 Jan 22. Review.
PMID: 23339055
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Select item 23301199
Cancer-linked targets modulated by curcumin.
Hasima N, Aggarwal BB.
Int J Biochem Mol Biol. 2012;3(4):328-51. Epub 2012 Dec 24.
PMID: 23301199 Free PMC Article
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Select item 23143785
Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB.
AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. Review.
PMID: 23143785 Free PMC Article
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Select item 23140290
Chemopreventive and chemotherapeutic potential of curcumin in breast cancer.
Sinha D, Biswas J, Sung B, Aggarwal BB, Bishayee A.
Curr Drug Targets. 2012 Dec;13(14):1799-819. Review.
PMID: 23140290
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Select item 22887802
Multitargeting by turmeric, the golden spice: From kitchen to clinic.
Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB.
Mol Nutr Food Res. 2013 Sep;57(9):1510-28. doi: 10.1002/mnfr.201100741. Epub 2012 Aug 13. Review.
PMID: 22887802
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Select item 22149093
Cancer cell signaling pathways targeted by spice-derived nutraceuticals.
Sung B, Prasad S, Yadav VR, Aggarwal BB.
Nutr Cancer. 2012;64(2):173-97. doi: 10.1080/01635581.2012.630551. Epub 2011 Dec 9. Review.
PMID: 22149093 Free PMC Article
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Select item 22147524
Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.
Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB.
Mol Nutr Food Res. 2012 Mar;56(3):454-65. doi: 10.1002/mnfr.201100270. Epub 2011 Dec 7.
PMID: 22147524 Free PMC Article
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Select item 22118895
Discovery of curcumin, a component of golden spice, and its miraculous biological activities.
Gupta SC, Patchva S, Koh W, Aggarwal BB.
Clin Exp Pharmacol Physiol. 2012 Mar;39(3):283-99. doi: 10.1111/j.1440-1681.2011.05648.x. Review.
PMID: 22118895 Free PMC Article
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Select item 21979811
Multitargeting by curcumin as revealed by molecular interaction studies.
Gupta SC, Prasad S, Kim JH, Patchva S, Webb LJ, Priyadarsini IK, Aggarwal BB.
Nat Prod Rep. 2011 Nov;28(12):1937-55. doi: 10.1039/c1np00051a. Epub 2011 Oct 6. Review.
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Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.
Anand P, Sung B, Kunnumakkara AB, Rajasekharan KN, Aggarwal BB.
Biochem Pharmacol. 2011 Dec 15;82(12):1901-9. doi: 10.1016/j.bcp.2011.09.001. Epub 2011 Sep 8. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:144.
PMID: 21924245 Free PMC Article
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Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.
Narayan V, Ravindra KC, Chiaro C, Cary D, Aggarwal BB, Henderson AJ, Prabhu KS.
J Mol Biol. 2011 Jul 29;410(5):972-83. doi: 10.1016/j.jmb.2011.04.013.
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Select item 21565893
Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents.
Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB.
Exp Biol Med (Maywood). 2011 Jun 1;236(6):658-71. doi: 10.1258/ebm.2011.011028. Epub 2011 May 12. Review.
PMID: 21565893 Free PMC Article
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Select item 21516481
Epigenetic changes induced by curcumin and other natural compounds.
Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB.
Genes Nutr. 2011 May;6(2):93-108. doi: 10.1007/s12263-011-0222-1. Epub 2011 Apr 24.
PMID: 21516481 Free PMC Article
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Select item 21466422
Curcumin and liver cancer: a review.
Darvesh AS, Aggarwal BB, Bishayee A.
Curr Pharm Biotechnol. 2012 Jan;13(1):218-28. Review.
PMID: 21466422
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Select item 21325634
Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.
Prakobwong S, Gupta SC, Kim JH, Sung B, Pinlaor P, Hiraku Y, Wongkham S, Sripa B, Pinlaor S, Aggarwal BB.
Carcinogenesis. 2011 Sep;32(9):1372-80. doi: 10.1093/carcin/bgr032. Epub 2011 Feb 16.
PMID: 21325634 Free PMC Article
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Select item 21191188
Curcumin: a component of the golden spice, targets multiple angiogenic pathways.
Yadav VR, Aggarwal BB.
Cancer Biol Ther. 2011 Jan 15;11(2):236-41. Epub 2011 Jan 15. No abstract available.
PMID: 21191188
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Select item 20924967
Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Goel A, Aggarwal BB.
Nutr Cancer. 2010;62(7):919-30. doi: 10.1080/01635581.2010.509835. Review.
PMID: 20924967
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A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.
Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB.
Cancer Chemother Pharmacol. 2011 Jul;68(1):157-64. doi: 10.1007/s00280-010-1470-2. Epub 2010 Sep 22.
PMID: 20859741 Free Article
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Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.
Prakobwong S, Khoontawad J, Yongvanit P, Pairojkul C, Hiraku Y, Sithithaworn P, Pinlaor P, Aggarwal BB, Pinlaor S.
Int J Cancer. 2011 Jul 1;129(1):88-100. doi: 10.1002/ijc.25656. Epub 2010 Nov 3.
PMID: 20824699 Free Article
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Select item 20737283
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
Gupta SC, Kim JH, Prasad S, Aggarwal BB.
Cancer Metastasis Rev. 2010 Sep;29(3):405-34. doi: 10.1007/s10555-010-9235-2. Review.
PMID: 20737283 Free PMC Article
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Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB.
Biochem Pharmacol. 2010 Dec 15;80(12):1833-43. doi: 10.1016/j.bcp.2010.07.021. Epub 2010 Jul 21. Review.
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Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, Parkkinen J, Aggarwal BB.
Biochem Pharmacol. 2010 Oct 1;80(7):1021-32. doi: 10.1016/j.bcp.2010.06.022. Epub 2010 Jun 23. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:142.
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Select item 20420526
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.
Aggarwal BB.
Annu Rev Nutr. 2010 Aug 21;30:173-99. doi: 10.1146/annurev.nutr.012809.104755. Review.
PMID: 20420526 Free PMC Article
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Select item 20393484
Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling.
Zhang C, Li B, Zhang X, Hazarika P, Aggarwal BB, Duvic M.
J Invest Dermatol. 2010 Aug;130(8):2110-9. doi: 10.1038/jid.2010.86. Epub 2010 Apr 15.
PMID: 20393484 Free Article
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Select item 20138025
Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.
Ravindran J, Subbaraju GV, Ramani MV, Sung B, Aggarwal BB.
Biochem Pharmacol. 2010 Jun 1;79(11):1658-66. doi: 10.1016/j.bcp.2010.01.033. Epub 2010 Feb 4.
PMID: 20138025 Free PMC Article
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Select item 19903839
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.
Kamat AM, Tharakan ST, Sung B, Aggarwal BB.
Cancer Res. 2009 Dec 1;69(23):8958-66. doi: 10.1158/0008-5472.CAN-09-2045. Epub 2009 Nov 10.
PMID: 19903839 Free Article
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Select item 19818349
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line.
Yodkeeree S, Ampasavate C, Sung B, Aggarwal BB, Limtrakul P.
Eur J Pharmacol. 2010 Feb 10;627(1-3):8-15. doi: 10.1016/j.ejphar.2009.09.052. Epub 2009 Oct 7.
PMID: 19818349
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Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF.
Carcinogenesis. 2009 Nov;30(11):1949-56. doi: 10.1093/carcin/bgp229. Epub 2009 Sep 30.
PMID: 19793800 Free PMC Article
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Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity.
Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB, Krishnan S.
Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534-42. doi: 10.1016/j.ijrobp.2009.06.034.
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Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB.
Biochem Pharmacol. 2010 Feb 1;79(3):330-8. doi: 10.1016/j.bcp.2009.09.003. Epub 2009 Sep 6. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:143.
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Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM.
Biochem Pharmacol. 2010 Jan 15;79(2):218-28. doi: 10.1016/j.bcp.2009.08.007. Epub 2009 Aug 12. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:145.
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Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB.
Int J Cancer. 2009 Nov 1;125(9):2187-97. doi: 10.1002/ijc.24593. Erratum in: Int J Cancer. 2010 Feb 1;126(3):799. Kuzhuvelil, Harikumar B [corrected to Harikumar, Kuzhuvelil B].
PMID: 19623659 Free Article
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Select item 19590964
Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
Ravindran J, Prasad S, Aggarwal BB.
AAPS J. 2009 Sep;11(3):495-510. doi: 10.1208/s12248-009-9128-x. Epub 2009 Jul 10. Review.
PMID: 19590964 Free PMC Article
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Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy.
Gupta V, Aseh A, Ríos CN, Aggarwal BB, Mathur AB.
Int J Nanomedicine. 2009;4:115-22. Epub 2009 Apr 20.
PMID: 19516890 Free PMC Article
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Select item 19482682
Nuclear factor-kappa B links carcinogenic and chemopreventive agents.
Ralhan R, Pandey MK, Aggarwal BB.
Front Biosci (Schol Ed). 2009 Jun 1;1:45-60. Review.
PMID: 19482682
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Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Sung B, Kunnumakkara AB, Sethi G, Anand P, Guha S, Aggarwal BB.
Mol Cancer Ther. 2009 Apr;8(4):959-70. doi: 10.1158/1535-7163.MCT-08-0905. Erratum in: Mol Cancer Ther. 2009 May;8(5):1398.
PMID: 19372569 Free PMC Article
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Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
Aggarwal BB, Sung B.
Trends Pharmacol Sci. 2009 Feb;30(2):85-94. doi: 10.1016/ Epub 2008 Dec 26. Review.
PMID: 19110321
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Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1.
Reuter S, Schnekenburger M, Cristofanon S, Buck I, Teiten MH, Daubeuf S, Eifes S, Dicato M, Aggarwal BB, Visvikis A, Diederich M.
Biochem Pharmacol. 2009 Feb 1;77(3):397-411. doi: 10.1016/j.bcp.2008.09.041. Epub 2008 Oct 18.
PMID: 18996094
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Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB.
Biochem Pharmacol. 2008 Dec 1;76(11):1590-611. doi: 10.1016/j.bcp.2008.08.008. Epub 2008 Aug 19. Review.
PMID: 18775680
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Select item 18769126
Prostate cancer and curcumin: add spice to your life.
Aggarwal BB.
Cancer Biol Ther. 2008 Sep;7(9):1436-40. Epub 2008 Sep 21. No abstract available.
PMID: 18769126
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Select item 18755156
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells.
Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M.
Biochem Pharmacol. 2008 Dec 1;76(11):1340-51. doi: 10.1016/j.bcp.2008.07.031. Epub 2008 Aug 3. Review.
PMID: 18755156
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Select item 18662800
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
Aggarwal BB, Harikumar KB.
Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jul 9. Review.
PMID: 18662800 Free PMC Article
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Phase II trial of curcumin in patients with advanced pancreatic cancer.
Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R.
Clin Cancer Res. 2008 Jul 15;14(14):4491-9. doi: 10.1158/1078-0432.CCR-08-0024.
PMID: 18628464 Free Article
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Select item 18612945
Potential of spice-derived phytochemicals for cancer prevention.
Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P.
Planta Med. 2008 Oct;74(13):1560-9. doi: 10.1055/s-2008-1074578. Epub 2008 Jul 8. Review.
PMID: 18612945
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Select item 18479807
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Kunnumakkara AB, Anand P, Aggarwal BB.
Cancer Lett. 2008 Oct 8;269(2):199-225. doi: 10.1016/j.canlet.2008.03.009. Epub 2008 May 13. Review.
PMID: 18479807
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Select item 18462866
Curcumin and cancer: an "old-age" disease with an "age-old" solution.
Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB.
Cancer Lett. 2008 Aug 18;267(1):133-64. doi: 10.1016/j.canlet.2008.03.025. Epub 2008 May 6. Review.
PMID: 18462866
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Select item 18384098
Multi-targeted therapy by curcumin: how spicy is it?
Goel A, Jhurani S, Aggarwal BB.
Mol Nutr Food Res. 2008 Sep;52(9):1010-30. doi: 10.1002/mnfr.200700354. Review.
PMID: 18384098
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Select item 18381954
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.
Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S.
Clin Cancer Res. 2008 Apr 1;14(7):2128-36. doi: 10.1158/1078-0432.CCR-07-4722.
PMID: 18381954 Free Article
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Select item 17999464
Bioavailability of curcumin: problems and promises.
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB.
Mol Pharm. 2007 Nov-Dec;4(6):807-18. Epub 2007 Nov 14. Review.
PMID: 17999464
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Select item 17900536
Curcumin as "Curecumin": from kitchen to clinic.
Goel A, Kunnumakkara AB, Aggarwal BB.
Biochem Pharmacol. 2008 Feb 15;75(4):787-809. Epub 2007 Aug 19. Review.
PMID: 17900536
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Select item 17645940
Role of curcumin in cancer therapy.
Shishodia S, Chaturvedi MM, Aggarwal BB.
Curr Probl Cancer. 2007 Jul-Aug;31(4):243-305. Review. No abstract available.
PMID: 17645940
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Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB.
Free Radic Biol Med. 2007 Aug 15;43(4):568-80. Epub 2007 May 16.
PMID: 17640567 Free PMC Article
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Curcumin: the Indian solid gold.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H.
Adv Exp Med Biol. 2007;595:1-75. Review.
PMID: 17569205
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Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK.
Clin Cancer Res. 2007 Jun 1;13(11):3423-30.
PMID: 17545551 Free Article
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Select item 17522064
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB.
Carcinogenesis. 2007 Aug;28(8):1765-73. Epub 2007 May 23.
PMID: 17522064
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Select item 17475558
Natural products as a gold mine for arthritis treatment.
Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB.
Curr Opin Pharmacol. 2007 Jun;7(3):344-51. Epub 2007 May 1. Review.
PMID: 17475558
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Select item 17440100
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB.
Cancer Res. 2007 Apr 15;67(8):3853-61.
PMID: 17440100 Free Article
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Select item 17395690
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.
Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y.
Mol Pharmacol. 2007 Jul;72(1):29-39. Epub 2007 Mar 29.
PMID: 17395690 Free Article
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Select item 17363495
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
Kamat AM, Sethi G, Aggarwal BB.
Mol Cancer Ther. 2007 Mar;6(3):1022-30.
PMID: 17363495 Free Article
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Select item 17341611
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Aggarwal BB, Sethi G, Ahn KS, Sandur SK, Pandey MK, Kunnumakkara AB, Sung B, Ichikawa H.
Ann N Y Acad Sci. 2006 Dec;1091:151-69. Review.
PMID: 17341611
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Select item 17240359
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
Aggarwal BB, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G.
Biochem Pharmacol. 2007 Apr 1;73(7):1024-32. Epub 2006 Dec 15. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:147.
PMID: 17240359
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Select item 17211725
"Spicing up" of the immune system by curcumin.
Jagetia GC, Aggarwal BB.
J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9. Review.
PMID: 17211725
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Select item 16996673
Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells.
Sharma C, Kaur J, Shishodia S, Aggarwal BB, Ralhan R.
Toxicology. 2006 Nov 10;228(1):1-15. Epub 2006 Aug 12.
PMID: 16996673
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Select item 16843665
Novel curcumin analogs targeting TNF-induced NF-kappaB activation and proliferation in human leukemic KBM-5 cells.
Zambre AP, Kulkarni VM, Padhye S, Sandur SK, Aggarwal BB.
Bioorg Med Chem. 2006 Nov 1;14(21):7196-204. Epub 2006 Jul 14.
PMID: 16843665
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Select item 16642480
Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).
Chakravarti N, Myers JN, Aggarwal BB.
Int J Cancer. 2006 Sep 15;119(6):1268-75.
PMID: 16642480 Free Article
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Select item 16563357
Molecular targets of dietary agents for prevention and therapy of cancer.
Aggarwal BB, Shishodia S.
Biochem Pharmacol. 2006 May 14;71(10):1397-421. Epub 2006 Feb 23. Review.
PMID: 16563357
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Select item 16387689
Curcumin: getting back to the roots.
Shishodia S, Sethi G, Aggarwal BB.
Ann N Y Acad Sci. 2005 Nov;1056:206-17.
PMID: 16387689
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Select item 16356126
Chemosensitization and radiosensitization of tumors by plant polyphenols.
Garg AK, Buchholz TA, Aggarwal BB.
Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. Review.
PMID: 16356126
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Select item 16243823
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.
Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE.
Clin Cancer Res. 2005 Oct 15;11(20):7490-8.
PMID: 16243823 Free Article
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Select item 16219905
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB.
Mol Pharmacol. 2006 Jan;69(1):195-206. Epub 2005 Oct 11.
PMID: 16219905 Free Article
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Select item 16023083
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
Shishodia S, Amin HM, Lai R, Aggarwal BB.
Biochem Pharmacol. 2005 Sep 1;70(5):700-13.
PMID: 16023083
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Select item 16007726
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.
Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R.
Cancer. 2005 Aug 15;104(4):879-90.
PMID: 16007726 Free Article
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Select item 15911972
PARP cleavage and caspase activity to assess chemosensitivity.
Bharti AC, Takada Y, Aggarwal BB.
Methods Mol Med. 2005;111:69-78.
PMID: 15911972
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Select item 15659827
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
Aggarwal BB, Shishodia S.
Ann N Y Acad Sci. 2004 Dec;1030:434-41. Review.
PMID: 15659827
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Select item 15489888
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.
Takada Y, Bhardwaj A, Potdar P, Aggarwal BB.
Oncogene. 2004 Dec 9;23(57):9247-58.
PMID: 15489888
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Select item 15488631
Role of chemopreventive agents in cancer therapy.
Dorai T, Aggarwal BB.
Cancer Lett. 2004 Nov 25;215(2):129-40. Review.
PMID: 15488631
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Select item 15476283
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R.
Cancer. 2004 Nov 15;101(10):2351-62.
PMID: 15476283 Free Article
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Select item 15461561
From chemoprevention to chemotherapy: common targets and common goals.
Aggarwal BB, Takada Y, Oommen OV.
Expert Opin Investig Drugs. 2004 Oct;13(10):1327-38. Review.
PMID: 15461561
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Select item 15252836
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.
Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB.
Int J Cancer. 2004 Sep 20;111(5):679-92. Erratum in: Int J Cancer. 2004 Dec 20;112(6):1086.
PMID: 15252836 Free Article
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Select item 15128775
Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.
Bharti AC, Takada Y, Aggarwal BB.
J Immunol. 2004 May 15;172(10):5940-7.
PMID: 15128775 Free Article
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Select item 15070700
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis.
Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB.
Blood. 2004 Apr 15;103(8):3175-84. Epub 2003 Dec 18.
PMID: 15070700 Free Article
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Select item 14500688
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.
Bharti AC, Donato N, Aggarwal BB.
J Immunol. 2003 Oct 1;171(7):3863-71.
PMID: 14500688 Free Article
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Select item 12807725
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.
Shishodia S, Potdar P, Gairola CG, Aggarwal BB.
Carcinogenesis. 2003 Jul;24(7):1269-79. Epub 2003 May 9.
PMID: 12807725
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Select item 12680238
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal BB, Kumar A, Bharti AC.
Anticancer Res. 2003 Jan-Feb;23(1A):363-98. Review.
PMID: 12680238
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Select item 12483537
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.
Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M, Aggarwal BB.
Oncogene. 2002 Dec 12;21(57):8852-61.
PMID: 12483537 Free Article
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Select item 12393461
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Bharti AC, Donato N, Singh S, Aggarwal BB.
Blood. 2003 Feb 1;101(3):1053-62. Epub 2002 Sep 5.
PMID: 12393461 Free Article
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Select item 11756235
Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.
Anto RJ, Mukhopadhyay A, Denning K, Aggarwal BB.
Carcinogenesis. 2002 Jan;23(1):143-50.
PMID: 11756235
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Select item 11753638
Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines.
Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB.
Oncogene. 2001 Nov 15;20(52):7597-609.
PMID: 11753638 Free Article
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Select item 9586949
Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.
Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB.
Biochem Pharmacol. 1998 Mar 15;55(6):775-83.
PMID: 9586949
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Select item 9215611
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.
Mehta K, Pantazis P, McQueen T, Aggarwal BB.
Anticancer Drugs. 1997 Jun;8(5):470-81.
PMID: 9215611
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Select item 7559628
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected].
Singh S, Aggarwal BB.
J Biol Chem. 1995 Oct 20;270(42):24995-5000. Erratum in: J Biol Chem 1995 Dec 15;270(50):30235.
PMID: 7559628 Free Article
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Select item 7511111
Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.
Reddy S, Aggarwal BB.
FEBS Lett. 1994 Mar 14;341(1):19-22.